TRANSFUSION MEDICINE

 EPIDEMIOLOGY REVIEW (TMER)

RELEVANT PUBLICATIONS

• Llewelyn CA, Hewitt PE, Knight RSG, Amar K, Cousens S, Mackenzie J, Will RG.  Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion.  Lancet 2004; 363: 417-421. 
• Peden AH, Head MW, Ritchie DL, Bell JE, Ironside JW.  Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient.  Lancet 2004; 364: 527-529.
• Health Protection Agency.  New case of transfusion-associated variant-CJD.  CDR Weekly 2006; 16(6).
• Hewitt PE, Llewelyn CA, Mackenzie J, Will RG.  Creutzfeldt-Jakob disease and blood transfusion:  results of the UK Transfusion Medicine Epidemiology Review study.  Vox Sanguinis 2006; 91: 221-230.
• Wroe SJ, Pal S, Siddique D, Hyare H, Macfarlane R, Joiner S, Linehan JM, Brandner S, Wadsworth JD, Hewitt P, Collinge J.  Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion:  a case report.  Lancet 2006; 368: 2061-2067.
• Health Protection Agency.  Fourth case of transfusion-associated variant-CJD infection.  Health Protection Report 2007; 1(3).
• Gillies M, Chohan G, Llewelyn CA, Mackenzie J, Ward HJT, Hewitt PE, Will RG.  A retrospective case note review of deceased recipients of vCJD-implicated blood transfusions.  Vox Sanguinis 2009; 97: 211-218.
• Ward HJT, Mackenzie JM, Llewelyn CA, Knight RSG, Hewitt PE, Connor N, Molesworth A, Will RG.  Variant Creutzfeldt-Jakob disease and exposure to fractionated products.  Vox Sanguinis 2009; 97: 207-210
• Chohan G, Llewelyn C, Mackenzie J, Cousens S, Kennedy A, Will RG, Hewitt PE.  Variant Creutzfeldt-Jakob disease in a transfusion recipient: coincidence or cause? Transfusion 2010; 50: 1003-1006.