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Data and Reports
Study of UK patients treated with growth hormone shows seeding of amyloid beta in the brain and blood vessels
A Department of Health-funded team at the National CJD Research & Surveillance Unit led by James Ironside and Diane Ritchie with collaborators in the Centre for Cognitive and Neural Systems, Edinburgh, Clinical Neurosciences, Cambridge and the UCL Great Ormond Institute of Child Health have performed a detailed study of 33 UK hGH-iCJD patients who died from 1991 to the present day. They looked at the accumulation of amyloid beta in these patients’ brains and compared the findings with amyloid beta accumulation in 12 other UK hGH recipients who died from causes other than CJD, and in age-matched patients with sporadic and variant CJD. The resulting paper by Diane Ritchie et al is published in Acta Neuropathologica this month.